Extracellular Thiol Isomerases and Their Role in Thrombus Formation
نویسندگان
چکیده
منابع مشابه
Thiol isomerases in thrombus formation.
Protein disulfide isomerase (PDI), ERp5, and ERp57, among perhaps other thiol isomerases, are important for the initiation of thrombus formation. Using the laser injury thrombosis model in mice to induce in vivo arterial thrombus formation, it was shown that thrombus formation is associated with PDI secretion by platelets, that inhibition of PDI blocked platelet thrombus formation and fibrin ge...
متن کاملStaphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases.
OBJECTIVE Staphylococcus aureus can induce platelet aggregation. The rapidity and degree of this correlates with the severity of disseminated intravascular coagulation, and depends on platelet peptidoglycans. Surface-located thiol isomerases play an important role in platelet activation. The staphylococcal extracellular adherence protein (Eap) functions as an adhesin for host plasma proteins. T...
متن کاملIntracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.
OBJECTIVE Thiol isomerases facilitate protein folding in the endoplasmic reticulum, and several of these enzymes, including protein disulfide isomerase and ERp57, are mobilized to the surface of activated platelets, where they influence platelet aggregation, blood coagulation, and thrombus formation. In this study, we examined the synthesis and trafficking of thiol isomerases in megakaryocytes,...
متن کاملA critical role for extracellular protein disulfide isomerase during thrombus formation in mice.
Thiol isomerases, including protein disulfide isomerase (PDI), catalyze disulfide oxidation, reduction, and isomerization, thereby playing an important role in protein synthesis. To determine whether extracellular PDI mediates thrombus formation in an animal model, PDI expression, platelet accumulation, and fibrin generation were monitored in the blood vessels of mice by intravital fluorescence...
متن کاملIntracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases
Crescente, M., Pluthero , F. G., Li, L., Lo, R. W., Walsh, T. G., Schenk, M. P., Holbrook, L. M., Loureiro, S., Ali, M. S., Vaiyapuri, S., Falet, H., Jones, I. M., Poole, A. W., Kahr, W. H. A. and Gibbins, J. M. (2016) Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arteriosclerosis Thrombosis and Vascular Biology, 36 (6). pp. 1164-1173. ISSN 1079-5...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2016
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2015.6530